Houston Texans vs San Francisco 49ers: Spread Analysis and Pick Prediction

The San Francisco 49ers host the Houston Texans in a battle of 2-2 teams that expected to be much better at this point in the season.

The 49ers have struggled against AFC South teams, but appeared to awaken from their slumber in a rout of the Rams. Meanwhile, the Texans are smarting from a terrible loss to Seattle.

Point spread: 49ers opened as 4.5-point favorites; the total was 42.5. (Line updates and Matchup report)

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