San Francisco 49ers vs. Arizona Cardinals: Betting Odds Analysis Pick Prediction

The San Francisco 49ers are 8-2 against the spread in their last 10 games against the Arizona Cardinals and even more profitable in the desert (7-1 ATS past eight visits here).

But Arizona is 6-1 straight up ("SU") at home this season. With playoff implications for both teams on the line, the Cardinals host the Niners Sunday afternoon.

49ers, Cardinals point spread: The 49ers vs. Cardinals game opened as even odds and remained there through Thursday—the total was 42.5. (Line updates and matchup report)

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